Samm reveals to Kira and the Senators, that the Partials are dying off. She begins her studies on him, but when the government attempts to use the captured Partial to gain total control over the society, Kira realizes she must free Samm and take him back to the mainland.
Although furious with her for doing so, the government gives Kira permission to study the Partial, named Samm, with the stipulation that after five days he will be destroyed. The sortie is successful and Kira manages to capture a male Partial. Undeterred Kira, organizes a group to go out to the mainland - to Manhattan, with the intent of capturing a Partial. When she approaches a senior researcher with her idea, she is told this is impossible. She believes that somehow there is a connection between the two. In order to do this, Kira realizes that they need to find a Partial and take samples or bring one back to study. Kira discovers that the virus has been studied from all possible angles, except the source - the Partials who are imimune. Up until now, researchers have been studying only the babies and she feels that there is something they are missing. When sixteen year old medic, Kira, learns that her friends, Madison and Haru, are expecting their first child, she is determined that she will find a cure for RM. It seems that there is no hope left for the remnants of humanity. Instead, all babies have continued to sicken at birth and to die hours later. To try to counter deaths caused by the RM virus, government enacted the Hope Act which required women of a certain age to have babies in the hope that some might survive. The youngest child, Saladin, is now fourteen years old. Since the Break, every human baby born has died from the RM virus. No one has seen a Partial in eleven years. Meanwhile, the Partials disappeared, retreating inland. There they organized a government consisting of twenty senators and built a Defense Grid to protect themselves. The survivors of the war and the virus, retreated to Long Island where they found food and shelter. Only a small percentage of humans were immune and survived the pandemic, but any children born afterwards, continued to die.
The Partials released the RM virus, a specially designed virus that quickly killed virtually every human being on the planet. Faster and stronger than ordinary humans, linked to one another and highly efficient, they easily wiped them out.
The Partials were built by a company called ParaGen to fight in the Isolation War, which they won handily. Mankind has been destroyed by the Partials who are genetically "engineered organic beings identical to humans". Partials tells the story of a post-apocalyptic society in what was the eastern seaboard of the United States in the year 2076.
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